• Artículo
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      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus 

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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      Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains 

      Jiménez Muñoz, Sebastián; Navarro Garrido, Victoria; Moyano González, Francisco Javier; Sánchez Mico, María; Torres Canalejo, Manuel; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014)
      The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease 

      Baglietto Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel María; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
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      Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

      García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
      Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
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      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology 

      Trujillo Estrada, Laura Isabel; Jiménez Muñoz, Sebastián; Castro, Vanessa de; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
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      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer 

      Trujillo Estrada, Laura Isabel; Castro, Vanesa de; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
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      Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease 

      Gómez Arboledas, Ángela; Dávila Cansino, José Carlos; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley, 2018)
      Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...